Quantumzyme has embarked on this journey to develop a machine learning framework to predict the properties of an enzyme with significant accuracy and we have, once again, surpassed our previous performances with this AI/ML-based enzyme engineering platform
Lignin being a robust material, is considered as useless due to its inhibitory effect on microbes because it acts as a physical barrier for cellulose degradation. Hence to produce high-value materials, it has been removed from cellulosic biomass.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged as a global pandemic that is severely affecting our daily life, economy, and putting tremendous pressure on the healthcare infrastructure. Undoubtedly, this is one of the greatest challenges faced by humankind after the World War II. Faced with the unprecedented nature of COVID-19, many vaccines, drug molecules have been fast-tracked in Phase I and Phase II trials. Unfortunately, there is still no proper treatment available till date1. However, several existing drug molecules such as ribavirin, interferon, lopinavir-ritonavir, corticosteroids, have been used in patients with SARS or MERS. Although the efficacy of some …
COVID-19 is a highly contagious disease, caused by a novel coronavirus called the SARS-CoV-2, leading to respiratory illness with symptoms like dry cough and high fever. The disease has emerged in Wuhan Hubei Province, China in late December 2019 and has been declared as pandemic on March, 2020 by WHO. Till today COVID-19 pandemic is spreading at an alarming rate and has reached to 10.1 millioncases and killed 502 thousand people worldwide as of June 29,2020. As the disease spreads if an infected person coughs or sneezes near the healthy person, social distancing with infected person is very critical to …
The pandemic of Coronavirus has become an everyday topic of discussion by affecting more than 8 million people globally. As India entered the top 5 list of Corona affected countries in the world, it has increased the urgency for a potential drug that can cure or at least reduce the effect of the virus. With scientists around the globe are testing different therapies on COVID affected patients, to find a cure for the disease, in parallel, researchers are also exploring the the therapeutic potential of existing drugs as an efficient immediate approach. From a study conducted on 1063 patients with …
What is nCOVID-19? The nCOVID-19 (Coronavirus disease of 2019) is part of a versatile family of viruses known as coronaviruses. The name coronavirus comes from the crown-like spikes on their surface. (Note: The virus is not related with Corona beer) Later renamed as “Severe Acute Respiratory Syndrome coronavirus 2,” or SARS-CoV-2 by the International Committee on Taxonomy of Viruses. As the name suggests the virus causes respiratory problems or lung infection majorly humans. SARS-CoV-2 (Severe acute respiratory syndrome) was first identified late last year and currently, there are 4 million active cases with nearly .3 million cases of deaths according to …
Textbooks often describe enzymes are highly efficient, have high rate of reaction, and much superior to that of a chemical catalyst. But how fast is it possible for an enzyme-catalyzed reaction to proceed? Is there any limit to the rate acceleration achievable by enzymes? The answer is yes, there is a certain upper limit to the rate acceleration by an enzyme and very few enzymes have achieved it.This special class of enzyme is known as “Diffusion Limited Enzyme. Diffusion Limited Enzyme The rate is limited by the rate at which the substrate can diffuse onto its active site and product …
A Bioinformatics View on How Corona Virus Binds to the Host Receptor Dr. Abhijit Kayal Senior Scientist, Quantumzyme In December 2019, a novel coronavirus, named SARS-CoV-2, emerged in Wuhan, China, and led to a rapidly spreading outbreak of coronavirus disease which is designated as COVID-19 by World Health Organisation (WHO).The coronavirusCOVID-19 is affecting 210 countries and territories. Till now the death toll rises to 1,68,784 (date: 20.04.2020).However, the world has already seen a similar pandemic in the year 2002 by a similar type of coronavirus SARS-CoV. The similarities between SARS-CoV and SARS-CoV-2 are striking, not only in name but also in their …
In the mid-1980s, there was a significant public concern on the huge amount of chemical waste generated by chemical and pharmaceutical industries. A paradigm shift was clearly needed from this traditional approach by the chemical industry with respect to the generation of hazardous and toxic waste. There was an immediate focus on cleaner chemistry, resource efficiency and bio-processes to produce less waste. This, alternative route, came to known as “Green Chemistry”. The industrial process of synthesizing different compounds largely depends on chemical catalysis where mostly heavy metals are used as a catalytic agent. Metals like rhodium, palladium, ruthenium are often …
Enzymes are bio-catalysts that help in accomplishing chemical reactions at benign conditions; not requiring toxic chemicals or elevated temperature and pressure conditions. Enzymes are made up of a combination of 20 naturally occurring amino-acids connected to each other like beads on a necklace. Indeed, our human body has about 75000 enzymes, which aid in metabolism and digestion. Similarly, organisms such as Bacteria, Yeast, Fungi have a myriad set of enzymes assisting their functions. In the industry, enzymes have found several applications — in poultry, agriculture, textiles, & synthesis of active pharmaceutical ingredients (API)s. Often the wild-type (WT) enzyme isolated from …