Quantum-Chemical Descriptors of Hydroxychloroquine and Remdesivir

bio-process

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged as a global pandemic that is severely affecting our daily life, economy, and putting tremendous pressure on the healthcare infrastructure. Undoubtedly, this is one of the greatest challenges faced by humankind after the World War II. Faced with the unprecedented nature of COVID-19, many vaccines, drug molecules have been fast-tracked in Phase I and Phase II trials.  Unfortunately, there is still no proper treatment available till date1.  However, several existing drug molecules such as ribavirin, interferon, lopinavir-ritonavir, corticosteroids, have been used in patients with SARS or MERS. Although the efficacy of some …

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COVID-19 Diagnosis: Current trends and Future Prospects

COVID19 Diagnosis

COVID-19 is a highly contagious disease, caused by a novel coronavirus called the SARS-CoV-2, leading to respiratory illness with symptoms like dry cough and high fever. The disease has emerged in Wuhan Hubei Province, China in late December 2019 and has been declared as pandemic on March, 2020 by WHO. Till today COVID-19 pandemic is spreading at an alarming rate and has reached to 10.1 millioncases and killed 502 thousand people worldwide as of June 29,2020. As the disease spreads if an infected person coughs or sneezes near the healthy person, social distancing with infected person is very critical to …

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A Chemical Space Travel of Clinical Trial Compounds for COVID-19

Remdesivir

The pandemic of Coronavirus has become an everyday topic of discussion by affecting more than 8 million people globally. As India entered the top 5 list of Corona affected countries in the world, it has increased the urgency for a potential drug that can cure or at least reduce the effect of the virus. With scientists around the globe are testing different therapies on COVID affected patients, to find a cure for the disease,  in parallel, researchers are also exploring the the therapeutic potential of existing drugs as an efficient immediate approach. From a study conducted on 1063 patients with …

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A Bioinformatics View on How Corona Virus Binds to the Host Receptor

Coronavirus

A Bioinformatics View on How Corona Virus Binds to the Host Receptor Dr. Abhijit Kayal Senior Scientist, Quantumzyme In December 2019, a novel coronavirus, named SARS-CoV-2, emerged in Wuhan, China, and led to a rapidly spreading outbreak of coronavirus disease which is designated as COVID-19 by World Health Organisation (WHO).The coronavirusCOVID-19 is affecting 210 countries and territories. Till now the death toll rises to 1,68,784 (date: 20.04.2020).However, the world has already seen a similar pandemic in the year 2002 by a similar type of coronavirus SARS-CoV. The similarities between SARS-CoV and SARS-CoV-2 are striking, not only in name but also in their …

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