Quantum-Chemical Descriptors of Hydroxychloroquine and Remdesivir

bio-process

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged as a global pandemic that is severely affecting our daily life, economy, and putting tremendous pressure on the healthcare infrastructure. Undoubtedly, this is one of the greatest challenges faced by humankind after the World War II. Faced with the unprecedented nature of COVID-19, many vaccines, drug molecules have been fast-tracked in Phase I and Phase II trials.  Unfortunately, there is still no proper treatment available till date1.  However, several existing drug molecules such as ribavirin, interferon, lopinavir-ritonavir, corticosteroids, have been used in patients with SARS or MERS. Although the efficacy of some …

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A Chemical Space Travel of Clinical Trial Compounds for COVID-19

Remdesivir

The pandemic of Coronavirus has become an everyday topic of discussion by affecting more than 8 million people globally. As India entered the top 5 list of Corona affected countries in the world, it has increased the urgency for a potential drug that can cure or at least reduce the effect of the virus. With scientists around the globe are testing different therapies on COVID affected patients, to find a cure for the disease,  in parallel, researchers are also exploring the the therapeutic potential of existing drugs as an efficient immediate approach. From a study conducted on 1063 patients with …

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